Chimeric embryos of equine mouse bred by scientists for the first time

wallpapers Industry 2020-10-20

is a scientific research team led by the University of Texas Dallas Southwest Medical Center Shenzhen Huada Institute of life sciences. For the first time

has cultivated a new stem cell line from a variety of species on this basis it has generated the world's first chimeric equine mouse embryo. The

research papers were published online on December 2 in the American Journal cell stem cell. This achievement has potential application in xenotransplantation endangered animal protection. One of the bases of the new research on

lies in the generation of chimeric embryonic stem cell lines. Previous studies have found that pluripotent stem cells (pluripotent stem cells) have two states i.e. the initial state the activated state which respectively represent the state before after implantation of embryos in vivo. However some scientists believe that there may be an intermediate state called "formative state". By activating three cell signaling pathways at the same time a stable stem cell line xpscs with this intermediate state has been developed for the first time. It can not only produce chimeric embryos efficiently but also differentiate into primordial germ cells in vitro. Wu Jun author of the

papers assistant professor of molecular biology at the University of Texas Dallas Southwest Medical Center told Xinhua that the new method is expected to be widely used to obtain more similar stem cells from mammals.

in addition to human xpscs cell lines researchers also used the same culture conditions to obtain xpscs cell lines from horses mice. After injecting xpscs cells from horses into mouse embryos researchers have successfully bred the world's first early chimeric equine mouse embryo.

in 2017 Wu Jun others published a paper in the American Journal cell announcing that human stem cells were injected into pig embryos successfully bred human pig chimeric embryos for the first time. Wu Jun said the new research is a further step forward for early research. To cultivate cell lines that can be used for heterozygous chimerism can further promote the research application of heterozygous chimerism.


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