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Regeneration of nerve cells in the eyeball may restore vision

wallpapers Industry 2020-06-30

according to an anti-aging research breakthrough published in the British journal Nature on the 2nd scientists from Harvard University Medical School reprogrammed the neurons of mouse eyes to a younger state so that their eyesight can be regenerated restored. This study further reveals the aging mechanism for human beings points out new potential targets for the treatment of age-related neuronal diseases such as glaucoma.

retinal ganglion cells are neurons in the eye that connect elongated parts (called axons) from the eye to the brain. These axons can survive regenerate if they are damaged early in development but not in adulthood.

this time David Sinclair a scientist from Harvard Medical School his colleagues have shown that the expression of three Yamanaka transcription factors namely Oct4 Sox2 KLF4 can reprogram these neurons to a younger state by expressing three Yamanaka transcription factors in retinal ganglion cells of mature mice with optic nerve damage. These mice developed new axons some of which extended to the base of the skull. The same treatment can reverse the loss of neurons restore the visual acuity. At the molecular level the damage repair of

seem to involve epigenetic variation such as methylation. When retinal ganglion cells are damaged molecules called methyl groups accumulate on their DNA. Neurons undergo demethylation during repair switching to a younger methylation mode. The results of

support the previous view that the accumulation of epigenetic variation is behind aging. It is possible to reverse the age of a complex tissue restore its biological function. In addition the study suggests that mammalian tissues retain a record of young information - partly encoded by DNA methylation - that improves tissue function.

in the "news opinion" article published at the same time as the new research Andrew Huberman a scientist at Stanford University School of medicine discussed whether the research results can be extended to human beings. The role of the transcription factors described in this paper needs to be further verified in humans but the results have suggested that they may be able to reprogram brain neurons of different species.


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