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Advanced materials: ultra high photothermal conversion efficiency (88.3%) of photothermal reagents for cancer photothermal therapy

wallpapers Nicaragua News 2020-10-11

cancer is one of the diseases with high incidence rate mortality worldwide. At present the main treatment methods used in clinic include surgery chemotherapy radiotherapy which are inefficient lack of selectivity to cancer tissue or have large toxic side effects. Therefore photothermotherapy (PTT) a new type of tumor therapy with high selectivity low side effects is becoming a hot spot of scientific research. PTT is a typical photon triggered therapy which kills tumor cells by local high temperature generated by photothermal reagent (PTA) under visible or near infrared (NIR) light excitation. Among the existing PTA organic materials with near-infrared absorption are considered to be the most promising which have good biocompatibility potential biodegradability high reproducibility. Photothermal conversion efficiency (PCE) is a key factor of PTA which directly determines the intensity of excitation light in the process of photothermal therapy. High intensity excitation light is easy to cause damage to skin tissue. Therefore improving the efficiency of photothermal conversion reducing the intensity of laser using safe intensity laser for photothermal therapy are the key points difficulties in the research field of PTT.

recently Professor Peng Xiaojun Associate Professor Sun Wen academician of Dalian University of technology have made new progress in the research of improving the photothermal conversion efficiency of photothermal reagents: introducing - CF3 at meso position of BODIPY dye as a rotating group to prepare efficient photothermal organic small molecule TFM BDP their characteristics are described in detail. The strong electron withdrawing group CF3 the strong electron donating group n N-dimethylamino are introduced into BODIPY molecule to form a strong D-A structure which can significantly improve the conjugated system red shift the absorption wavelength improve the absorption coefficient photothermal properties. At the same time under the irradiation of NIR (808 nm) laser TFM BDP causes the rotation of - CF3 barrier which makes the excited state of TFM BDP reach the ground state through the ultra-high efficiency non radiative transition path thus converting the light energy into heat energy to the maximum extent. Interestingly the twisted TFM BDP molecular skeleton can inhibit parallel ladder π − π stacking (H-aggregation). Therefore when TFM BDP is encapsulated in polymer nanoparticles the barrier rotation can be maintained in the aggregation state. TFM BDP NPs has a high efficiency of photothermal conversion of 88.3%. Even if low-intensity laser irradiation (808 nm 0.3 Wcm-2) can significantly improve the treatment temperature TFM BDP NPs in vitro in vivo experiments have achieved excellent therapeutic effect. Especially in the mouse tumor inhibition experiment TFM BDP NPs accumulated effectively in the tumor site for the first time under the safe NIR laser intensity (808 nm 1 3 W cm-2) leads to complete tumor ablation. Therefore the development of this photothermal reagent can overcome the light damage to healthy skin tissue caused by the use of high-intensity laser in vivo experiments has important biomedical value. The researchers of

believe that the design strategy of powerless barrier rotation provides a new platform for the innovative design of photothermal reagents opens up a prospect for the clinical application of photothermal reagents.

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