Small: Iron death induced by redox MOF for cancer treatment

iron death (ferroptosis) is a cell death pattern different from apoptosis autophagy necrosis discovered in recent years which has attracted extensive attention of researchers all over the world. Accumulation of lipid peroxide (LPO) in tumor site can lead to iron death. Glutathione peroxidase 4 (GPx4) is a key protein in the iron death pathway. It can transform LPO into non-toxic alcohol (LOH) in cells. By inhibiting the activity of GPx4 in cells it can block the antioxidant system in cells lead to iron death. In addition hydroxyl radical Oh can react with intracellular liposomes to produce LPO cause iron death.

based on this Shuai Xintao Shen Jun of Sun Yat sen University have prepared a metal organic framework nanoparticles with redox response containing iron copper disulfide bonds（ PFP@Fe/Cu-SS MOF）。 The MOF can consume GSH through disulfide mercaptan exchange reaction redox reaction between metal ions glutathione (GSH) thus inhibiting the activity of GPx4 increasing the content of LPO. At the same time the MOF can react with H2O2 enriched in tumor cells to generate hydroxyl radical Oh · Oh then react with liposomes to generate LPO which further increases the content of LPO eventually leads to cell iron death. In addition the MOF can be used as a contrast agent photothermal photosensitizer for T1 magnetic resonance imaging which can induce photothermal therapy under near-infrared radiation convert encapsulated liquid perfluoropentane (PFP) into microbubbles for ultrasound imaging. The research results provide a new idea for the research development of iron death nano medicine.

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