European fertiliser companies, which rely on natural gas to produce key nutrients, are now having to cut back again. At least a quarter of Europe's nitrogen fertilizer production capacity has been lost, according to media reports. The International Fertilizer Council predicts that global nitrogen use will fall the most in the coming quarter since 2008.
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Sars-cov-2 variants from chronic COVID infection are of concern, which has an impact on the market for viral nucleic acid
A new study strongly suggests that worrisome variants of the coronavirus are emerging from chronic, long-term COVID infections in people who may have immune function and are unable to clear the virus. Frontiers in Virology published the results of a study by scientists at Emory and Oxford Universities.
"Our results evolve not from a chain of transmission of acute COVID infections in hundreds of millions of people, but from rare cases where someone may persist with an infection for months," says corresponding author Daniel Weissman, a professor of biology and physics at Emory University who focuses on quantitative evolutionary theory.
The researchers used existing data and software they developed to build a mechanistic theoretical model to study the problem. The resulting model rules out the theory that VOC arises from sustained transmission of acute infection and fully supports the theory that each variant evolved in a single individual with chronic infection.
The model shows how multiple mutations are required, each of which may be neutral or slightly advantageous for viral fitness. In this way, a variant eventually acquires a series of mutations that make it easier to spread.
While the current paper draws from data on alpha, beta, and gamma variants, the resulting theoretical model also explains the later independent emergence of Delta and Omicron VOC. Delta emerged in India in late 2020, quickly sweeping the country and spreading globally. Delta faded after Omicron (not a descendant of the Delta variant) appeared in South Africa in late 2021. Omicron quickly became the world's leading VOC.
"Ideally, we'd like to eventually be able to quantify when new variants are likely to emerge in the future," Weissman said. "From a public health perspective, this has huge implications."
Studies have shown that some immunocompromised people, such as those taking medications for other chronic conditions, have been carrying active COVID infections for a year or more. The researchers stress that identifying these people is crucial, not only to help them receive treatment for COVID, but also to conduct genomic surveillance of the SARS-CoV-2 virus they carry.
Analysis and forecast of the market size of PCR diagnostic industry
Polymerase chain reaction (PCR) is a nucleic acid synthesis technology that uses the principle of DNA double-strand replication to replicate specific DNA fragments in vitro. With this technology, the detection equipment can amplify the target gene in a large number in a short time, expanding the target gene fragment to the order of millions to billions, thus achieving high sensitivity detection. At present, polymerase chain reaction (PCR) diagnosis of infectious diseases such as hepatitis, venereal disease, intestinal respiratory disease and tumor single gene detection is an important application field. In 2020, polymerase chain reaction (PCR) diagnostic technology was identified as the "gold standard" for COVID-19 diagnosis due to its high sensitivity and accuracy.
China's PCR diagnostic market is developing rapidly, with the market size growing rapidly from about RMB 2.37 billion in 2015 to about RMB 5.93 billion in 2019, with a compound annual growth rate of 25.8%. China's PCR industry experienced explosive growth due to the huge demand for testing caused by the outbreak of COVID-19 in 2020, and the market size of China's PCR diagnostic industry exceeded 10 billion yuan in 2020. With the introduction of a large number of PCR diagnostic instruments, the PCR diagnostic industry will enter a new stage of development. It is expected that the PCR diagnostic industry will maintain a double-digit growth rate, and the market size of the PCR diagnostic industry will reach about 23.42 billion yuan in 2030 based on the factory price, and the cagR will reach about 13.3% from 2019 to 2030.
Market Demand of the viral nucleic acid
The DNA/RNA Extraction Kit market and other viral nucleic acid s are projected to grow at a CAGR of 8.26% during the forecast period 2022-2027.
The COVID-19 pandemic has impacted the viral nucleic acid market for a short time due to restrictions on different business and research activities for viral nucleic acid s. In addition, diagnostic tests for other diseases and medical conditions in hospitals and other clinical diagnostic facilities have been affected as COVID-19 has led to fewer patients taking tests. However, the high rate of COVID-19 infection and research activities are undertaken by major companies in the field of sequencing to expand their understanding of the virus and its origins, as well as molecular diagnostics of the SARS-COV-2 virus, have led to the development and launch of many DNA - and RNA-BASED COVID-19 kits, The kits proved so important that they were in great demand.
Market drivers for the viral nucleic acid
The growth of the DNA/RNA extraction kit market is primarily driven by increased investment in R&D activities in different areas, including molecular diagnostics for different chronic and infectious diseases. For example, the US spent $842 billion on R&D activities in 2020, followed by China at $664 billion, according to the ORGANISATION for Economic Co-operation and Development. Technological advances worldwide, new product launches by major market players, and an increase in cancer cases are also likely to complement the growth of the markets under study.
Other factors, such as increased demand for automation of DNA/RNA extraction technologies, new user-friendly and easy extraction kits, and DNA/RNA for analysis of new diseases causing microorganisms, are expected to drive DNA/RNA growth. RNA Extraction Kit market during the forecast period. Therefore, low awareness and availability of the kit and low market penetration in less developed and developing regions around the world are the major factors limiting the growth of the DNA/RNA extraction kit market.
North America is expected to dominate the global viral nucleic acid market during the forecast period
North America, which holds a major share in the viral nucleic acid market, is expected to show a similar trend during the forecast period, mainly due to the high level of R&D activity in the region and the presence of major market players in the region constantly developing their products for the markets studied.
In the region, the US is expected to take a major share of the DNA/RNA extraction kit market due to heavy investment in R&D by government and private entities, increased demand for viral nucleic acid s, and the rising prevalence of chronic diseases.
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